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Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

《化学科学与工程前沿（英文）》 2022年 第16卷 第3期   页码 333-344 doi: 10.1007/s11705-021-2059-5

摘要： Compared to conventional hyperthermia that is limited by low selectivity and severe side effects, nano-enabled hyperthermia yields great potentials to tackle these limitations for cancer treatment. Another major advance is the observation of immunological responses associated with nano-enabled hyperthermia, which introduces a new avenue, allowing a potential paradigm shift from the acutely effective and cytotoxicity-centric response to the next-phase discovery, i.e., long-lasting and/or systemic anti-tumor immunity. This perspective first discusses the temperature-gradient and the spatially-structured immunological landscape in solid tumors receiving nano-enabled hyperthermia. This includes the discussion about underlying mechanism such as immunogenic cell death, which initiates a profound immunological chain reaction. In order to propagate the immune activation as a viable therapeutic principle, we further discussed the tumor type-specific complexity in the immunological tumor microenvironment, including the creative design of nano-enabled combination therapy to synergize with nano-enabled hyperthermia.

关键词： nano-enabled hyperthermia     immunogenic cell death     heterogeneous immunological landscape     tumor microenvironment    

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Plasma-enabled healing of graphene nano-platelets layer

Xiuqi Fang, Carles Corbella, Denis B. Zolotukhin, Michael Keidar

《化学科学与工程前沿（英文）》 2019年 第13卷 第2期   页码 350-359 doi: 10.1007/s11705-018-1787-7

摘要： Graphene platelet networks (GPNs) were deposited onto silicon substrates by means of anodic arc discharge ignited between two graphite electrodes. Substrate temperature and pressure of helium atmosphere were optimized for the production of the carbon nanomaterials. The samples were modified or destroyed with different methods to mimic typical environments responsible of severe surface degradation. The emulated conditions were performed by four surface treatments, namely thermal oxidation, substrate overheating, exposition to glow discharge, and metal coating due to arc plasma. In the next step, the samples were regenerated on the same substrates with identical deposition technique. Damaging and re-growth of GPN samples were systematically characterized by scanning electron microscopy and Raman spectroscopy. The full regeneration of the structural and morphological properties of the samples has proven that this healing method by arc plasma is adequate for restoring the functionality of 2D nanostructures exposed to harsh environments.

关键词： graphene platelet networks     anodic arc discharge     plasma healing     scanning electron microscopy     Raman spectroscopy    

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Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

null

《医学前沿（英文）》 2014年 第8卷 第1期   页码 1-5 doi: 10.1007/s11684-014-0309-3

摘要：

Hyperthermia is a condition characterized by increased body temperature as a consequence of failed thermoregulation. Hyperthermia occurs when a body produces or absorbs more heat than it dissipates. Hyperthermia also elicits various effects on the physiology of living cells. For instance, fever-range temperature (39β°C to 40β°C) can modulate the activities of immune cells, including antigen-presenting cells, T cells, and natural killer cells. Heat shock temperature (41β°C to 43β°C) can increase the immunogenicity of tumor cells. Cytotoxic temperature (>43β°C) can create an antigen source to induce an anti-tumor immune response. The immunomodulatory effect of hyperthermia has promoted an interest in hyperthermia-aided immunotherapy, particularly against tumors. Hyperthermia has also been used to treat deep fungal, bacterial, and viral skin infections. We conducted a series of open or controlled trials to treat skin human papillomavirus infection by inducing local hyperthermia. More than half of the patients were significantly cured compared with those in the control trial. A series of challenging clinical cases, such as large lesions in pregnant patients or patients with diabetes mellitus, were also successfully and safely managed using the proposed method. However, further studies should be conducted to clarify the underlying mechanisms and promote the clinical applications of hyperthermia.

关键词： hyperthermia     HPV     immune response     virus     tumor    

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Machine learning enabled prediction and process optimization of VFA production from riboflavin-mediated

《环境科学与工程前沿（英文）》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1735-8

摘要：

● Data-driven approach was used to simulate VFA production from WAS fermentation.

关键词： Machine learning     Volatile fatty acids     Riboflavin     Waste activated sludge     eXtreme Gradient Boosting    

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Liquid metal enabled combinatorial heat transfer science: toward unconventional extreme cooling

Xiao-Hu YANG, Jing LIU

《能源前沿（英文）》 2018年 第12卷 第2期   页码 259-275 doi: 10.1007/s11708-017-0521-3

摘要： As a class of newly emerging material, liquid metal exhibits many outstanding performances in a wide variety of thermal management areas, such as thermal interface material, heat spreader, convective cooling and phase change material (PCM) for thermal buffering etc. To help mold next generation unconventional cooling technologies and further advance the liquid metal cooling to an ever higher level in tackling more extreme, complex and critical thermal issues and energy utilizations, a novel conceptual scientific category was dedicated here which could be termed as combinatorial liquid metal heat transfer science. Through comprehensive interpretations on a group of representative liquid metal thermal management strategies, the most basic ways were outlined for developing liquid metal enabled combined cooling systems. The main scientific and technical features of the proposed hybrid cooling systems were illustrated. Particularly, five abstractive segments toward constructing the combinatorial liquid metal heat transfer systems were clarified. The most common methods on innovating liquid metal combined cooling systems based on this classification principle were discussed, and their potential utilization forms were proposed. For illustration purpose, several typical examples such as low melting point metal PCM combined cooling systems and liquid metal convection combined cooling systems, etc. were specifically introduced. Finally, future prospects to search for and make full use of the liquid metal combined high performance cooling system were discussed. It is expected that in practical application in the future, more unconventional combination forms on the liquid metal cooling can be obtained from the current fundamental principles.

关键词： combinatorial heat transfer     liquid metal     high flux cooling     thermal management    

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Anticorrosive composite self-healing coating enabled by solar irradiation

《化学科学与工程前沿（英文）》 2022年 第16卷 第9期   页码 1355-1366 doi: 10.1007/s11705-022-2147-1

摘要： Self-healing coatings for long-term corrosion protection have received much interest in recent years. However, most self-healing coatings rely on healants released from microcapsules, dynamic bonds, shape memory, or thermoplastic materials, which generally suffer from limited healing times or harsh conditions for self-healing, such as high temperature and UV radiation. Herein, we present a composite coating with a self-healing function under easily accessible sunlight by adding Fe3O4 nanoparticles and tetradecanol into epoxy resin. Tetradecanol, with its moderate melting point, and Fe3O4 nanoparticles serve as a phase-change component and photothermal material in an epoxy coating system, respectively. Fe3O4 nanoparticles endow this composite self-healing coating with good photothermal properties and a rapid thermal response time under simulated solar irradiation as well as outdoor real sunlight. Tetradecanol can flow to and fill defects by phase transition at low temperatures. Therefore, artificial defects created in this type of self-healing coating can be healed by the liquified tetradecanol induced by the photothermal effect of Fe3O4 nanoparticles under simulated solar irradiation. The healed coating can still serve as a good barrier for the protection of the underlying carbon steel. These excellent properties make this self-healing coating an excellent candidate for various engineering applications.

关键词： self-healing coating     phase transition     photothermal effect     corrosion protection    

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Digital twin-enabled smart facility management: A bibliometric review

《工程管理前沿（英文）》 doi: 10.1007/s42524-023-0254-4

摘要： In recent years, the architecture, engineering, construction, and facility management (FM) industries have been applying various emerging digital technologies to facilitate the design, construction, and management of infrastructure facilities. Digital twin (DT) has emerged as a solution for enabling real-time data acquisition, transfer, analysis, and utilization for improved decision-making toward smart FM. Substantial research on DT for FM has been undertaken in the past decade. This paper presents a bibliometric analysis of the literature on DT for FM. A total of 248 research articles are obtained from the Scopus and Web of Science databases. VOSviewer is then utilized to conduct bibliometric analysis and visualize keyword co-occurrence, citation, and co-authorship networks; furthermore, the research topics, authors, sources, and countries contributing to the use of DT for FM are identified. The findings show that the current research of DT in FM focuses on building information modeling-based FM, artificial intelligence (AI)-based predictive maintenance, real-time cyber–physical system data integration, and facility lifecycle asset management. Several areas, such as AI-based real-time asset prognostics and health management, virtual-based intelligent infrastructure monitoring, deep learning-aided continuous improvement of the FM systems, semantically rich data interoperability throughout the facility lifecycle, and autonomous control feedback, need to be further studied. This review contributes to the body of knowledge on digital transformation and smart FM by identifying the landscape, state-of-the-art research trends, and future needs with regard to DT in FM.

关键词： digital twin     building information modeling     facility management     semantic interoperability     artificial intelligence     intelligent monitoring     autonomous control feedback    

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Toward resilient cloud warehousing via a blockchain-enabled auction approach

《工程管理前沿（英文）》   页码 20-38 doi: 10.1007/s42524-022-0224-2

摘要： Cloud warehousing service (CWS) has emerged as a promising third-party logistics service paradigm driven by the widespread use of e-commerce. The current CWS billing method is typically based on a fixed rate in a coarse-grained manner. This method cannot reflect the true service value under the fluctuating e-commerce logistics demand and is not conducive to CWS resilience management. Accordingly, a floating mechanism can be considered to introduce more flexible billing. A CWS provider lacks sufficient credibility to implement floating mechanisms because it has vested interests in terms of fictitious demand. To address this concern, this report proposes a blockchain-enabled floating billing management system as an overall solution for CWS providers to enhance the security, credibility, and transparency of CWS. A one-sided Vickrey–Clarke–Groves (O-VCG) auction mechanism model is designed as the underlying floating billing mechanism to reflect the real-time market value of fine-grained CWS resources. A blockchain-based floating billing prototype system is built as an experimental environment. Our results show that the O-VCG mechanism can effectively reflect the real-time market value of CWSs and increase the revenue of CWS providers. When the supply of CWS providers remains unchanged, allocation efficiency increases when demand increases. By analyzing the performance of the O-VCG auction and comparing it with that of the fixed-rate billing model, the proposed mechanism has more advantages. Moreover, our work provides novel managerial insights for CWS market stakeholders in terms of practical applications.

关键词： resilient cloud warehousing     blockchain technology     floating billing management system     auction mechanism     third-party logistics    

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Micro/nanofluidics-enabled energy conversion and its implemented devices

Yang YANG, Jing LIU

《能源前沿（英文）》 2011年 第5卷 第3期   页码 270-287 doi: 10.1007/s11708-010-0126-6

摘要： Most people were not aware of the role of energy as a basic force that drives the development and economic growth of the world until the two great oil crises occurred. According to the conservation law, energy not only exists in various forms but is also capable of being converted from one form to another. The common forms of energy are mechanical energy, chemical energy, internal energy, electrical energy, atomic energy, and electromagnetic energy, among others. The fluids in nature serve as the most common carriers and media in the energy conversion process. Following the rapid development of microelectromechanical systems (MEMS) technology, the energy supply and conversion issue in micro/nano scale has also been introduced in research laboratories worldwide. With unremitting efforts, great quantities of micro/nano scale energy devices have been investigated. Micro/nanofluid shows distinct features in transporting and converting energy similar to their counterpart macroscale tasks. In this paper, a series of micro/nanofluid-enabled energy conversion devices is reviewed based on the transformation between different forms of energy. The evaluation and contradistinction of their performances are also examined. The role of micro/nanofluid as media in micro/nano energy devices is summarized. This contributes to the establishment of a comprehensive and systematic structure in the relationship between energy conversion and fluid in the micro/nano scale. Some fundamental and practical issues are outlined, and the prospects in this challenging area are explored.

关键词： micro/nanofluid     different energy forms     energy conversion     medium role    

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Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

《工程管理前沿（英文）》   页码 82-95 doi: 10.1007/s42524-022-0233-1

摘要： During the COVID-19 pandemic, the current operating environment of pharmaceutical supply chain (PSC) has rapidly changed and faced increasing risks of disruption. The Internet of Things (IoT) and blockchain not only help enhance the efficiency of PSC operations in the information technology domain but also address complex related issues and improve the visibility, flexibility, and transparency of these operations. Although IoT and blockchain have been widely examined in the areas of supply chain and logistics management, further work on PSC is expected by the public to enhance its resilience. To respond to this call, this paper combines a literature review with semi-structured interviews to investigate the characteristics of PSC, the key aspects affecting PSC, and the challenges faced by PSC in the post-pandemic era. An IoT–blockchain-integrated hospital-side oriented PSC management model is also developed. This paper highlights how IoT and blockchain technology can enhance supply chain resilience and provides a reference on how PSC members can cope with the associated risks.

关键词： pharmaceutical supply chain     Internet of Things     blockchain     resilience     post-pandemic era    

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Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1548-1

摘要：

• Water-dispersible nano-pollutions exhibit type-specific toxic effects on E. coli.

关键词： Nano-toxicity     Nano-plastics     Quantum dots     Microbial metabolite     Metabolic dysregulation    

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Laboratory investigation of emulsified asphalt binder modified with wood-derived nano-cellulose and nano

Yunge WEI; Jiayu WANG; Ruoyu LI; Ling XU; Feipeng XIAO

《结构与土木工程前沿（英文）》 2022年 第16卷 第11期   页码 1474-1485 doi: 10.1007/s11709-022-0869-2

摘要： Emulsified asphalt is the primary material for preventive maintenance and cold-mix paving, but its low cohesive strength and poor mechanical properties limit its wide application, even with polymer modification. In this study, Styrene-Butadiene Rubber (SBR) emulsified asphalt was modified with nano-cellulose materials, namely nano paper-cellulose (NPC) and wood-derived nano-cellulose (WDC), to improve its properties. A novel preparation method of nano-cellulose solution was developed, including blending, ultrasonic stirring, and centrifugal treatment. Four types of nano-cellulose solution (0.5% NPC, 0.5%, 1.0%, and 1.5% WDC by weight of water) were selected. The microscopy analysis indicated that 0.5% WDC emulsion had a smaller particle size than 1.5% WDC emulsion. The rheology test indicated that WDC modified residue improved rutting resistance with the increased solution dosage due to the cross-linking effect, but its creep-and-recovery performance was worse than that of SBR emulsion residue. The NPC modified binder had a higher rutting factor than WDC modified binder at the same dosage after short-term aging. In addition, 1.0% WDC could be regarded as the optimal dosage in terms of fatigue and low-temperature performance. Furthermore, Fourier Transform Infrared Spectroscopy (FTIR) results showed that 0.5% NPC modified residue performed better in long-term aging resistance compared with 0.5%WDC modified asphalt.

关键词： nano-cellulose     emulsified asphalt binder     dispersion     rheological properties     Fourier transform infrared spectroscopy    

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Enhanced methane production during long-term UASB operation at high organic loads as enabled by the immobilized

《环境科学与工程前沿（英文）》 2022年 第16卷 第6期 doi: 10.1007/s11783-021-1505-4

摘要：

• Fungi enable the constant UASB operation even at OLR of 25.0 kg/(m3×d).

关键词： Anaerobic digestion     Fungi     Methane production     High OLR     Microbial community    

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Pd nano-catalyst supported on biowaste-derived porous nanofibrous carbon microspheres for efficient catalysis

《化学科学与工程前沿（英文）》 2023年 第17卷 第9期   页码 1289-1300 doi: 10.1007/s11705-023-2299-7

摘要： Environmental pollution caused by the presence of aromatic aldehydes and dyes in wastewater is a serious global concern. An effective strategy for the removal of these pollutants is their catalytic conversion, possibly to valuable compounds. Therefore, the design of efficient, stable and long-lifetime catalysts is a worthwhile research goal. Herein, we used nanofibrous carbon microspheres (NCM) derived from the carbohydrate chitin present in seafood waste, and characterized by interconnected nanofibrous networks and N/O-containing groups, as carriers for the manufacture of a highly dispersed, efficient and stable Pd nano-catalyst (mean diameter ca. 2.52 nm). Importantly, the carbonised chitin’s graphitized structure, defect presence and large surface area could promote the transport of electrons between NCM and Pd, thereby endowing NCM supported Pd catalyst with high catalytic activity. The NCM supported Pd catalyst was employed in the degradation of some representative dyes and the chemoselective hydrogenation of aromatic aldehydes; this species exhibited excellent catalytic activity and stability, as well as applicability to a broad range of aromatic aldehydes, suggesting its potential use in green industrial catalysis.

关键词： biowaste chitin     nanofibrous     palladium     nano-catalyst     catalysis    

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Cobalt nitride enabled benzimidazoles production from furyl/aryl bio-alcohols and -nitroanilines without

《化学科学与工程前沿（英文）》 2023年 第17卷 第1期   页码 68-81 doi: 10.1007/s11705-022-2174-y

摘要： Benzimidazole derivatives have wide-spectrum biological activities and pharmacological effects, but remain challenging to be produced from biomass feedstocks. Here, we report a green hydrogen transfer strategy for the efficient one-pot production of benzimidazoles from a wide range of bio-alcohols and o-nitroanilines enabled by cobalt nitride species on hierarchically porous and recyclable nitrogen-doped carbon catalysts (Co/CNx-T, T denotes the pyrolysis temperature) without using an external hydrogen source and base additive. Among the tested catalysts, Co/CNx-700 exhibited superior catalytic performance, furnishing 2-substituted benzimidazoles in 65%–92% yields. Detailed mechanistic studies manifest that the coordination between Co2+ and N with appropriate electronic state on the porous nitrogen-doped carbon having structural defects, as well as the remarkable synergetic effect of Co/N dual sites contribute to the pronounced activity of Co/CNx-700, while too high pyrolysis temperature may cause the breakage of the catalyst Co–N bond to lower down its activity. Also, it is revealed that the initial dehydrogenation of bio-alcohol and the subsequent cyclodehydrogenation are closely correlated with the hydrogenation of nitro groups. The catalytic hydrogen transfer-coupling protocol opens a new avenue for the synthesis of N-heterocyclic compounds from biomass.

关键词： biomass conversion     furanic compounds     benzimidazoles     hydrogen transfer     bifunctional catalysis    

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标题 作者 时间 类型 操作

Immunological effects of nano-enabled hyperthermia for solid tumors: opportunity and challenge

期刊论文

Plasma-enabled healing of graphene nano-platelets layer

Xiuqi Fang, Carles Corbella, Denis B. Zolotukhin, Michael Keidar

期刊论文

Hyperthermia on skin immune system and its application in the treatment of human papillomavirus-infected

null

期刊论文

Machine learning enabled prediction and process optimization of VFA production from riboflavin-mediated

期刊论文

Liquid metal enabled combinatorial heat transfer science: toward unconventional extreme cooling

Xiao-Hu YANG, Jing LIU

期刊论文

Anticorrosive composite self-healing coating enabled by solar irradiation

期刊论文

Digital twin-enabled smart facility management: A bibliometric review

期刊论文

Toward resilient cloud warehousing via a blockchain-enabled auction approach

期刊论文

Micro/nanofluidics-enabled energy conversion and its implemented devices

Yang YANG, Jing LIU

期刊论文

Internet of Things (IoT)–blockchain-enabled pharmaceutical supply chain resilience in the post-pandemic

期刊论文

Water-dispersible nano-pollutions reshape microbial metabolism in type-specific manners: A metabolic

期刊论文

Laboratory investigation of emulsified asphalt binder modified with wood-derived nano-cellulose and nano

Yunge WEI; Jiayu WANG; Ruoyu LI; Ling XU; Feipeng XIAO

期刊论文

Enhanced methane production during long-term UASB operation at high organic loads as enabled by the immobilized

期刊论文

Pd nano-catalyst supported on biowaste-derived porous nanofibrous carbon microspheres for efficient catalysis

期刊论文

Cobalt nitride enabled benzimidazoles production from furyl/aryl bio-alcohols and -nitroanilines without

期刊论文